Table 3.
Cox proportional hazard regression model-based multivariate analysis of patients with MSI-H colorectal cancer (n = 216)
| Variables | n | Univariate analysis | P value | Multivariate analysis | P value |
|---|---|---|---|---|---|
|
|
|
||||
| H.R. (95% C.I.) | H.R. (95% C.I.) | ||||
| Nuclear maspin expression | |||||
| Maspin-negative (0/1+) | 105 | 1 (reference) | 1 (reference) | ||
| Maspin-positive (2+/3+) | 111 | 1.91 (1.08-3.4) | 0.027 | 1.41 (0.77-2.56) | 0.265 |
| AJCC/UICC TNM stage | |||||
| Stage I/II | 139 | 1 (reference) | 1 (reference) | ||
| Stage III/IV | 77 | 4.34 (2.44-7.72) | < 0.001 | 3.26 (1.77-6.02) | < 0.001 |
| Tumor differentiation | |||||
| WD/MD | 171 | 1 (reference) | 1 (reference) | ||
| PD | 45 | 3.01 (1.71-5.29) | < 0.001 | 1.95 (1.08-3.52) | 0.027 |
| CIMP | |||||
| CIMP-L/0 | 160 | 1 (reference) | 1 (reference) | ||
| CIMP-H | 56 | 2.36 (1.35-4.12) | 0.003 | 1.34 (0.68-2.63) | 0.401 |
| Age | |||||
| Younger (< 58 years) | 102 | 1 (reference) | 1 (reference) | ||
| Older (≥ 58 years) | 114 | 1.63 (0.92-2.87) | 0.094 | 1.33 (0.69-2.58) | 0.394 |
Abbreviations: H.R., Cox hazard ratio; 95% C.I., 95% confidence interval of H.R.; AJCC/UICC, American Joint Committee on Cancer/International Union against Cancer; TNM, tumor-node-metastasis; WD, well differentiated; MD, moderately differentiated; PD, poorly differentiated; CIMP, CpG island methylator phenotype; CIMP-L/0, CIMP-low or CIMP-negative; CIMP-H, CIMP-high.