Table 3.
Top 10 pathways enriched by the target genes of differentially expressed microRNAs
| Pathway name | Total gene | P-value | Genes |
|---|---|---|---|
| Ribosome | 87 | 2.70E-11 | RPL13, RPL15, RPL27A, RPL36, RPS2, etc. |
| Spliceosome | 126 | 3.44E-09 | ISY1, SNRPD2, SF3A1, SF3B2, HSPA8, etc. |
| Lysine degradation | 44 | 3.74E-05 | SETDB1, DLST, EHMT1, SETD1A, SUV39H1, etc. |
| Cell cycle | 125 | 1.09E-04 | MCM4, CCNE2, CDK4, CCND2, HDAC2, etc. |
| Glycolysis/Gluconeogenesis | 60 | 0.0013266 | HK1, PGAM1, ALDOA, ALDOC, ALDH1B1, etc. |
| Pathways in cancer | 328 | 0.0017572 | HSP90AB1, E2F3, HRAS, FGF9, SPI1, etc. |
| Pancreatic cancer | 72 | 0.0030168 | E2F3, RALBP1, ERBB2, TGFBR1, SMAD4, etc. |
| Huntington’s disease | 180 | 0.0035936 | ATP5E, ATP5B, CYC1, NDUFAB1, CYTB, etc. |
| Parkinson’s disease | 128 | 0.0048767 | ATP5E, ND4, SLC25A5, ND5, ATP5B, etc. |
| Adherens junction | 77 | 0.0058749 | FGFR1, PARD3, ACTN4, ERBB2, TGFBR1, etc. |