Table 2.
Association between rs111188381 genotypes and colorectal cancer
| Model | Genotype | Females | Males | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Controls | Cases | OR (95% CI) | P-value | Controls | Cases | OR (95% CI) | P-value | ||
| Co-dominant | A/A | 46 (41.1%) | 43 (57.3%) | 1.00 | 0.036* | 99 (53.8%) | 72 (60.0%) | 1.00 | 0.64 |
| C/A | 55 (49.1%) | 29 (38.7%) | 0.53 (0.28-0.99) | 72 (39.1%) | 41 (34.2%) | 0.78 (0.47-1.30) | |||
| C/C | 11 (9.8%) | 3 (4.0%) | 0.27 (0.07-1.04) | 13 (7.1%) | 7 (5.8%) | 0.91 (0.32-2.61) | |||
| Dominant | A/A | 46 (41.1%) | 43 (57.3%) | 1.00 | 0.018* | 99 (53.8%) | 72 (60.0%) | 1.00 | 0.36 |
| C/A-C/C | 66 (58.9%) | 32 (42.7%) | 0.49 (0.27-0.89) | 85 (46.2%) | 48 (40.0%) | 0.80 (0.49-1.30) | |||
| Recessive | A/A-C/A | 101 (90.2%) | 72 (96%) | 1.00 | 0.11 | 171 (92.9%) | 113 (94.2%) | 1.00 | 1,00 |
| C/C | 11 (9.8%) | 3 (4.0%) | 0.37 (0.10-1.36) | 13 (7.1%) | 7 (5.8%) | 1.00 (0.36-2.83) | |||
| Over-dominant | A/A-C/C | 57 (50.9%) | 46 (61.3%) | 1.00 | 0.13 | 112 (60.9%) | 79 (65.8%) | 1.00 | 0.35 |
| C/A | 55 (49.1%) | 29 (38.7%) | 0.63 (0.34-1.14) | 72 (39.1%) | 41 (34.2%) | 0.79 (0.47-1.30) | |||
| Log-additive | - | - | - | 0.52 (0.32-0.87) | 0.01* | - | - | 0.86 (0.57-1.29) | 0.46 |
*
P ≤ 0.05.