Table 3.
Association between rs12724393 genotypes and colorectal cancer
| Model | Genotype | Females | Males | ||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| Controls | Cases | OR (95% CI) | P-value | Controls | Cases | OR (95% CI) | P-value | ||
| Co-dominant | C/C | 75 (67.0%) | 64 (83.1%) | 1.00 | 0.018* | 141 (76.6%) | 91 (75.2%) | 1.00 | 0.64 |
| C/G | 35 (31.2%) | 13 (16.9%) | 0.42 (0.20-0.87) | 42 (22.8%) | 27 (22.3%) | 0.95 (0.53-1.70) | |||
| G/G | 2 (1.8%) | 0 (0.0%) | 0.00 (0.00-NA) | 1 (0.5%) | 3 (2.5%) | 5.64 (0.47-67.99) | |||
| Dominant | C/C | 75 (67.0%) | 64 (83.1%) | 1.00 | 0.0091* | 141 (76.6%) | 91 (75.2%) | 1.00 | 0.36 |
| C/G-G/G | 37 (33.0%) | 13 (16.9%) | 0.40 (0.19-0.82) | 43 (23.4%) | 30 (24.8%) | 1.03 (0.59-1.82) | |||
| Recessive | C/C-C/G | 110 (98.2%) | 77 (100%) | 1.00 | 0.14 | 183 (99.5%) | 118 (97.5%) | 1.00 | 1.00 |
| G/G | 2 (1.8%) | 0 (0.0%) | 0.00 (0.00-NA) | 1 (0.5%) | 3 (2.5%) | 5.71 (0.47-68.55) | |||
| Over-dominant | C/C-G/G | 77 (68.8%) | 64 (83.1%) | 1.00 | 0.019* | 142 (77.2%) | 94 (77.7%) | 1.00 | 0.35 |
| C/G | 35 (31.2%) | 13 (16.9%) | 0.43 (0.21-0.89) | 42 (22.8%) | 27 (22.3%) | 0.93 (0.52-1.65) | |||
| Log-additive | - | - | - | 0.40 (0.20-0.80) | 0.0062* | - | - | 1.13 (0.67–1.90) | 0.66 |
*
P ≤ 0.05.