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. 2015 Feb 1;8(2):1503–1514.

Figure 1.

Figure 1

OPN expression in normal colonic epithelium and colorectal carcinoma: (A) Weak cytoplasmic expression in a small number of normal gland epithelial cells (negative expression). (B) Well differentiated adenocarcinoma showing weak cytoplasmic OPN expression. Surrounding macrophages exhibited strong positivity. (C) Moderately differentiated adenocarcinoma showing intense cytoplasmic OPN expression. (D) Poorly differentiated adenocarcinoma showing moderate cytoplasmic OPN expression [Immunohistochemistry, original magnification, (A-D) × 400].