Table 2.

Twenty-three reported cases of EB virus-positive plasma cell tumors

Case	Age (y)/gender	Underlying disease	Treatment of underlying disease	Clinical findings	Type of myeloma	Time from onset of underlying disease to onset of myeloma (y)	Treatment of myeloma	Therapeutic response	Outcome	Reference
1	11/F	None	None	Osteolytic lesion	IgA/κ/MM	-	Systemic steroid/RT/DEXA/Thal	Remission	Alive Elective for HSCT	[11]
2	78/M	None	None	Left submaxillary gland mass/osteolytic lesion	Plasmacytoma	-	Ex	Unknown	Unknown	[12]
3	40/M	Unknown	Unknown	Plasmacytoma/no osteolytic lesion	Plasmacytoma Bone marrow invasion plasmablastic	Unknown	Ex/RT	Remission maintained for 75 m	Alive 75 m	[13]
4	27/M	Unknown	Unknown	Osteolytic lesion	IgG/MM nonplasmablastic	Unknown	CT	Remission maintained for 30 m	DOMM 74 m	[13]
5	60/M	Unknown	Unknown	Osteolytic lesion	IgG/MM plasmablastic	Unknown	CT/RT	Remission maintained for 67 m	DOMM 97 m	[13]
6	51/M	Unknown	Unknown	Osteolytic lesion	IgG/MM plasmablastic	Unknown	CT	Not improved	DOMM 5 m	[13]
7	Unknown/Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	[14]
8	Unknown/Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	Unknown	[14]
9	47/M	Chronic renal failure	Renal transplantation, CsA/AZA/PSL	Extramedullary mass/no osteolytic lesion	IgG-κ type plasmacytoma high-grade anaplastic plasmacytoma	12	Immunosuppressants discont’d/CY/PSL/RT	CR maintained	Died of respiratory tract infection 2 m later	[15]
10	49/F	None	None	Ileum ulcer	Plasmacytoma λ	-	Unknown	Unknown	Unknown	[16]
11	46/M	None	None	Stomach nodular	Plasmacytoma κ	-	Unknown	Unknown	Unknown	[16]
12	Unknown/Unknown	Unknown	Unknown	Head and neck extramedullary mass	Unknown	Unknown	Unknown	Unknown	Unknown	[17]
13	Unknown/Unknown	Unknown	Unknown	Head and neck extramedullary mass	Unknown	Unknown	Unknown	Unknown	Unknown	[17]
14	Unknown/Unknown	Unknown	Unknown	Head and neck extramedullary mass	Unknown	Unknown	Unknown	Unknown	Unknown	[17]
15	52/M	Hepatic failure and renal failure	Hepato-renal transplantation CsA/PSL/ALG/AZA/mPSL	Multiple pelvic soft tissue tumor	IgG-κ type plasmacytoma	1.4	CsA discont’d/RT	Complete remission maintained for 24 m	Alive 24 m	[18]
16	30/M	HIV	None	Gingival mass/maxillary soft tissue mass & destructive bone lesion/skin nodules	Anaplastic plasmacytoma κ	4	RT	Improved	Died 4 m later	[19]
17	34/M	HIV	None	Short breath Abdominal pain Ascites Dementia	Immature plasma cell λ	3	RT	Improved	Died 5 days later	[19]
18	41/M	Hodgkin’s lympho-ma	Curative therapy	Plasmacytoma involving skin and testis	Plasmacytoma κ	7	Unknown	Unknown	Unknown	[20]
19	51/Unknown	Unknown	Liver transplantationCsA	Periumbilical plasmacy-toma	Plasmacytoma κ	Unknown	Unknown	Unknown	Unknown	[20]
20	31/M	HIV	Unknown	Fever/confusion/slurred speech/progressive lethargy/polyuria polydypsia/left tonsillar mass/lung mass	IgG/κ IgM/λ Plasmablast Leukemic visceral and meningeal involvement	Unknown	Unknown	Unknown	Died of aspiration pneumonia	[21]
21	1.2/M	Unknown	Organ transplantation/CsA/PSL/AZA	Purulent rhinorrhea/difficulty breathing/recurrent otitis media/nasopharyngeal mass	Nasopharyngeal mass focal infiltration of plasmacells	0.9	Ex/immunosuppressant dose reduction	Improved	Unknown	[22]
22	61/F	RA	SASP/MTX/TAC/PSL	None	IgG/κ/MM	5.4	MTX discont’d/BD/Auto-PBSCT	CR	Surviving with CR, 12 m	Subject case

y, year; F, female; RT, radiation therapy; DEXA, dexamethasone; Thal, thalidomide; HSCT, hematopoietic stem cell transplantation; M, male; Ex, excision; m, month; CT, chemotherapy; DOMM, dead of multiple myeloma; CsA, cyclosporine; AZA, azathioprine; CY, cyclophosphamide; ALG, antilymphocyte globulin; mPSL, methylprednisolone; Auto-PBSCT, autologous peripheral blood stem cell transplantation.