Table 3.
Summary of 23 reported cases of EB virus-positive plasma cell tumors
Patients | n = 22 |
Age (y)/gender | n = 17 |
1.2-78 (46) | |
Unknown: 5 | |
n = 16 | |
M:F = 13:3 | |
Unknown: 6 | |
Underlying disease | n = 11 |
None: 4 | |
Chronic renal failure: 2 | |
Hepatic failure: 1 | |
HIV: 3 | |
Hodgkin’s lymphoma: 1 | |
RA: 1 | |
Unknown: 11 | |
Treatment | n = 12 |
None: 6 | |
Organ transplantation: 4 | |
CsA: 4 | |
AZA: 3 | |
PSL: 5 | |
ALG: 1 | |
SASP: 1 | |
MTX: 1 | |
TAC: 1 | |
Unknown: 10 | |
Clinical findings | n = 20 |
Extramedullary mass: 12 | |
Bone lesion: 5 | |
Ileum ulcer: 1 | |
Shortness of breath: 1 | |
Abdominal pain: 1 | |
Ascites: 1 | |
Dementia: 1 | |
Fever: 1 | |
Clouding of consciousness: 1 | |
Lethargy: 1 | |
Polyuria: 1 | |
Polydysplasia: 1 | |
Slurred speech: 1 | |
Purulent rhinorrhea: 1 | |
Dyspnea: 1 | |
Otitis media: 1 | |
None: 1 | |
Unknown: 2 | |
Type of myeloma | n = 17 |
IgA: 1 | |
IgG: 7 | |
IgM: 1 | |
κ: 9 | |
λ: 3 | |
Plasmacytoma: 11 | |
Plasmablastic: 4 | |
Non-plasmablastic: 1 | |
Time from onset of underlying disease to that of myeloma (yr) | n = 7 |
0.9-12 (median: 4) | |
No underlying disease: 4 | |
Unknown: 11 | |
Treatment of myeloma | n = 12 |
Corticosteroids (incl. PSL): 2 | |
DEXA: 2 | |
RT: 7 | |
Ex: 3 | |
CT: 4 | |
Thal: 1 | |
BD: 1 | |
Auto-PBSCT: 1 | |
Immunosuppressants discont’d or dose reduced: 4 | |
Unknown: 10 | |
Therapeutic response | n = 11 |
Remission (improved): 10 | |
Not improved: 1 | |
Unknown: 11 | |
Outcome | n = 11 |
Surviving: 4 | |
DOMM: 3 | |
Died of infection: 2 | |
Died, cause unknown: 2 | |
Unknown: 11 |