Table 1.

Partially characterized resistance nodulation cell division (RND) efflux pumps in Burkholderia species.

Species	Efflux pump	Gene names	Gene annotation	Major substrates	Reference
Burkholderia cenocepacia
	RND-1	NA	BCAS0591–BCAS0593	Non-detectable	Buroni et al. (2009)
	RND-3	NA1	BCAL1674–BCAL1676	Nalidixic acid, ciprofloxacin, tobramycin, chlorhexidine3	Buroni et al. (2009, 2014), Coenye et al. (2011)
	RND-4	NA2	BCAL2820–BCAL2822	Aztreonam, chloramphenicol, fluoroquinolones, tobramycin	Bazzini et al. (2011b)
	RND-8	NA	BCAM0925–BCAM0927	Tobramycin3	Buroni et al. (2014)
	RND-9	NA	BCAM1945–BCAM1947	Tobramycin3, chlorhexidine3	Coenye et al. (2011), Buroni et al. (2014)
	RND-10	ceoAB-opcM4	BCAM2551–BCAM2549	Chloramphenicol, fluoroquinolones, trimethoprim	Nair et al. (2004)
B. pseudomallei
	AmrAB-OprA	amrAB-oprA	BPSL1804–BPSL1802	Aminoglycosides, macrolides, cethromycin	Moore et al. (1999), Mima et al. (2011)
	BpeAB-OprB	bpeAB-oprB	BPSL0814–BPSL0816	Chloramphenicol, fluoroquinolones, macrolides, tetracyclines5	Chan et al. (2004), Mima and Schweizer (2010)
	BpeEF-OprC	bpeEF-oprC	BPSS0292–BPSS0294	Chloramphenicol, fluoroquinolones, tetracyclines, trimethoprim6	Kumar et al. (2006), Schweizer (2012a,b)
B. thailandensis
	AmrAB-OprA	amrAB-oprA	BTH_I2445–BTH_I2443	Aminoglycosides, macrolides, tetracyclines	Biot et al. (2013)
	BpeAB-OprB	bpeAB-oprB	BTH_I0680–BTH_I0682	Tetracyclines	Biot et al. (2013)
	BpeEF-OprC	bpeEF-oprC	BTH_II2106–BTH_II2104	Chloramphenicol, fluoroquinolones, tetracyclines, trimethoprim/sulfamethoxazole	Biot et al. (2011, 2013)
B. vietnamiensis
	AmrAB-OprM	amrAB-oprM	Bcep1808_1574–Bcep1808_1576	Aminoglycosides	Jassem et al. (2014)

NA, not applicable

¹Corresponds to B. pseudomallei amrAB-oprA

²Corresponds to B. pseudomallei bpeAB-oprB

³Sessile (biofilm grown) cells only

⁴Corresponds to B. pseudomallei bpeEF-oprC

⁵Low-level resistance in de-repressed (ΔbpeR) strains

⁶High-level resistance in regulatory mutants, e.g., bpeT carboxy-terminal mutations