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. 2014 Dec 16;2(1):ofu117. doi: 10.1093/ofid/ofu117

Figure 2.

Figure 2.

Partial least squares discriminant analysis (PLSDA) reveals elite controller (EC) plasma profiles of inflammatory markers are distinct from human immunodeficiency virus (HIV)-negative and HIV-suppressed profiles. (A) Partial least squares discriminant analysis identified a multivariate profile of 11 inflammatory markers that was able to classify ECs with 86% classification accuracy and 85% cross-validation accuracy (green dots, elite controllers; blue dots, HIV negative; red dots, HIV suppressed). (B) Latent variable 1 (LV1) represents the multivariate profile that differentiates EC from HIV-uninfected and HIV-suppressed, indicating that the EC profile was associated with elevation of soluble CD14 (sCD14), interferon-γ-inducible protein (IP)-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, macrophage inflammatory protein (MIP)-1β, sCD40L, interleukin (IL)-1β, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor (GM-CSF), and reduced RANTES. (C) Classification error rates of the 3 most highly predictive markers and all markers in combination. Abbreviation: VIP, variable importance projection.