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. 2015 Apr 2;8:689–697. doi: 10.2147/OTT.S80047

Figure 1.

Figure 1

BMS-536924 reduces viability of both TMZ-sensitive and -resistant glioma cells.

Notes: (A and B) M059K and U87MG cells were induced to become TMZ-resistant cells (M059K-R and U87MG-R) by incubation with gradually increased doses (2~20 μM) of TMZ for 4 months. The TMZ sensitivity was then examined using a cell viability assay. (C and D) Both TMZ-sensitive and -resistant cells were treated with BMS-536924 (12.5~800 nM) for 72 hours, followed by measurement of cell viability. (E and F) Both TMZ-sensitive and -resistant cells were treated with BMS-536924 (400 nM) for 24, 48, or 72 hours, followed by measurement of cell viability.

Abbreviation: TMZ, temozolomide.