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BMS-536924 suppresses phosphorylation of IGF-1R and IR in both TMZ-sensitive and -resistant glioma cells.
Notes: M059K-R and U87MG-R cells were seeded in six-well plates and incubated for 24 hours. Then the medium was replaced with serum-free medium, and BMS-536924 (200 and 800 nM) was added and incubated for 6 hours. Finally, the cells were stimulated with 30 ng/mL IGF-1 or 3 μg/mL insulin for 30 minutes, then were lysed and analyzed by western blot, using the indicated antibodies.
