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. 2015 Apr 2;8:689–697. doi: 10.2147/OTT.S80047

Figure 4.

Figure 4

BMS-536924 inhibits migration of both TMZ-sensitive and -resistant glioma cells.

Notes: (A) TMZ-resistant and -sensitive cells were treated with BMS-536924 (10, 40, or 160 nM) for 8 hours. The nonmigrated cells on the upper surface of the filter were removed, and the migrated cells on the lower side were stained and photographed. The representative images are shown. Then, cells were lysed, and colorimetric determination was made at 595 nm. (B) Quantitation of the inhibition from Transwell® assay. (C) A scratch was introduced into a monolayer of TMZ-resistant and -sensitive cells, followed by treatment with BMS-536924 (10, 40, or 160 nM) for 8 hours. The width of the wounded cell monolayer was measured in five random fields, and representative images are shown. (D) Quantitation of the inhibition from the wound healing assay.

Abbreviation: TMZ, temozolomide.