Figure 5.

BMS-536924 suppresses M059K-R and M059K tumor growth in vivo.

Notes: (A and B) After inoculation of M059K-R and M059K cells, BMS-536924 (20 and 40 mg/kg) was injected in mice every day. The tumors were measured every other day, and the tumor volumes are shown. (C) BMS-536924-induced apoptosis of M059K-R tumor cells in vivo was examined with TUNEL assay (green), DAPI staining (blue), or H&E staining (purple); the apoptotic cells were labeled with arrowheads. (D) BMS-536924 had no significant cytotoxic effects on the body weight of mice during the treatments.

Abbreviations: DAPI, 4′,6-diamidino-2-phenylindole; H&E, hematoxylin and eosin; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.