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. 2015 Mar 16;125(4):1648–1664. doi: 10.1172/JCI74440

Figure 3. Clinical relevance of candidate tumor cell migration hits in BC metastasis-free survival.

Figure 3

Gene expression data of a lymph node–negative BC patient cohort (n = 344) without prior treatment were used. Expression of identified tumor cell migration genes was correlated with MFS, and hazard ratio (HR) and Cox P values were calculated for ER-negative (n = 123) and -positive (n = 221) BC patients as well as all patients combined. Eight of 30 validated genes showed clinical relevance (2-sided P < 0.05, boldface in Supplemental Table 2). Kaplan-Meier curves are shown for genes with highest HR for MFS, drawn after determination of the optimal cutoff point (low log-rank P value). Low expression is represented by blue lines, and high expression by red lines.