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. 2015 Mar 9;125(4):1713–1725. doi: 10.1172/JCI78578

Figure 5. Depletion of CXCL9-producing neutrophils and macrophages protects against L. monocytogenes infection–induced fetal wastage.

Figure 5

(A) Percentage of resorbed fetuses 5 days after L. monocytogenes ΔactA (107 CFU) infection initiated midgestation (E11.5) among C57BL/6 female mice bearing allogeneic pregnancies after mating with BALB/c males that were administered anti-Gr1 compared with isotype control antibody (500 μg per mouse) 1 day prior to infection. (B) Representative FACS plots and composite data showing the percentage of fetal-OVA257–264-specific cells (CD90.1+) among CD8+ T cells recovered from the decidua 3 days after L. monocytogenes ΔactA (107 CFU) infection for C57BL/6 female mice bearing allogeneic pregnancies after mating with BALB/c-OVA males that were administered anti-Gr1 compared with isotype control antibody (500 μg per mouse) 1 day prior to infection. Each symbol reflects the data from a single mouse, and these results, containing 5–7 mice per group, are representative of 3 independent experiments, each with similar results. Error bars represent mean ± 1 SEM. Differences between the indicated groups were evaluated using a 2-tailed unpaired Student’s t test.