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. 2015 Mar 26;7(1):34. doi: 10.1186/s13148-015-0064-6

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© Acevedo et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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mRNA levels of genes harbouring age-modified CpG sites based on the FANTOM5 consortium data. (A) CAGE-defined TSS expression profiles for the age-methylated genes NGEF, SEPT5 and PDE2A in purified primary leukocytes and brain tissues. (B) CAGE-defined TSS expression profiles for the age-demethylated genes PTGER4 and PRDM16 and the age-methylated gene SNED1; mRNA levels are presented in transcripts per million (TPM, y-axis). Forty-five samples from blood and neuronal lineages as evaluated by the FANTOM5 consortium [43] are represented in the x-axis. Detailed information on the samples included in this comparison is presented in Additional file 8.