Table 2.
Age-methylated regions within 3 to 60 months after birth in blood leukocytes
| Gene symbol | Gene name | Function | Locus | Number of CpGs | Illumina ID | Region length (bp) |
|---|---|---|---|---|---|---|
| TTC22 | Tetratricopeptide repeat domain 22 | Mediate protein-protein interactions and chaperone activity | 1p32.3 | 3 | cg24550149 | 454 |
| cg15645660 | ||||||
| cg11949335 | ||||||
| SPEG | SPEG complex locus | Myocyte cytoskeletal development and marker of differentiated vascular smooth cells | 2q35 | 3 | cg14074251 | 51,924 |
| cg26530345 | ||||||
| cg02557933 | ||||||
| SNED1 | Sushi, nidogen and EGF-like domains 1 | Membrane-bound signalling molecule; hormonal regulation | 2q37.3 | 5 | cg02532017 | 34,671 |
| cg07644939 | ||||||
| cg25241559 | ||||||
| cg19075225 | ||||||
| cg17053285 | ||||||
| TRIM7 | Tripartite motif containing 7 | Ubiquitin protein ligase; Initiation of glycogen synthesis | 5q35.3 | 2 | cg17279652 | 170 |
| cg26600753 | ||||||
| DDR1 | Discoidin domain receptor tyrosine kinase 1 | Regulation of cell growth, differentiation and metabolism; cell communication with environment | 6p21.3 | 3 | cg16215084 | 238 |
| cg00934322 | ||||||
| cg09965419 | ||||||
| TNXB | Tenascin XB | Anti-adhesive effect; matrix maturation during wound healing | 6p21.3 | 3 | cg19071976 | 51,088 |
| cg16662408 | ||||||
| cg02657865 | ||||||
| MAD1L1 | MAD1 mitotic arrest deficient-like 1 | Mitotic spindle-assembly checkpoint; cell cycle control and tumour suppression | 7p22 | 6 | cg13700912 | 182,950 |
| cg06555468 | ||||||
| cg19513987 | ||||||
| cg16026522 | ||||||
| cg09174162 | ||||||
| cg00963171 | ||||||
| UPP1 | Uridine phosphorylase 1 | Phosphorolysis of uridine to free bases and ribose-1-phosphate | 7p12.3 | 3 | cg14983135 | 170 |
| cg10317717 | ||||||
| cg21484940 | ||||||
| ZNF503 | Zinc finger protein 503 | TF; transcriptional regulation; neural precursor cell proliferation | 10q22.2 | 2 | cg13997975 | 553 |
| cg03487027 | ||||||
| DGKZ | Diacylglycerol kinase, zeta | Kinase; regulate diacylglycerol levels in intracellular signal transduction | 11p11.2 | 2 | cg18908017 | 3,940 |
| cg09802018 | ||||||
| B4GALNT1 | Beta-1,4-N-acetyl-galactosaminyl transferase 1 | Biosynthesis of G(M2) and G(D2) glycosphingolipids | 12q13.3 | 2 | cg09932758 | 1,936 |
| cg25663970 | ||||||
| BTBD11 | BTB (POZ) domain containing 11 | Transcription cofactor; Protein heterodimerization activity (?) | 12q23.3 | 3 | cg27567561 | 566 |
| cg13935577 | ||||||
| cg01478234 | ||||||
| TEPP | Testis, prostate and placenta expressed | Unknown | 16q21 | 2 | cg12499872 | 91 |
| cg00491255 | ||||||
| CNTNAP1 | Contactin-associated protein 1 | Recruitment and activation of intracellular signalling pathways in neurons | 17q21 | 2 | cg16308533 | 39 |
| cg11629889 | ||||||
| TBCD | Tubulin folding cofactor D | Folding of beta-tubulin | 17q25.3 | 2 | cg16555866 | 35,310 |
| cg00663986 | ||||||
| NFIX | Nuclear factor I/X CCAAT-binding transcription factor | Transcription factor (TF) | 19p13.3 | 4 | cg06458248 | 9,812 |
| cg27392771 | ||||||
| cg01634146 | ||||||
| cg10767662 | ||||||
| LRFN1 | Leucine-rich repeat and fibronectin type III domain containing 1 | Promotes neurite outgrowth in hippocampal neurons. Regulates and maintain excitatory synapses | 19q13.2 | 2 | cg26910511 | 100 |
| cg25156118 | ||||||
| TMC2 | Transmembrane channel-like 2 | Ion channel; expression in the inner ear suggests that it may be crucial for normal auditory function | 20p13 | 3 | cg12233487 | 146 |
| cg23648082 | ||||||
| cg03243506 | ||||||
| CLDN5 | Claudin 5 | Claudin (physical barrier to solutes); membrane protein and tight junctions | 22q11.21 | 2 | cg04463638 | 366 |
| cg14553765 |