Figure 1.

GF and HM colonic segments show similar contractile responses to exogenous, luminal 5-HT ex vivo. A) Intracolonic pressure was measured in midcolonic segments ex vivo (arrowhead indicates migrating contraction). B) Representative recordings from GF and HM segments, with and without addition of luminal 5-HT (10 μM). C) Basal contractile frequency of HM and GF colonic segments (4 mice per group). Student’s t test: P > 0.05. D) Mean contractile duration (seconds) measured at half-maximal amplitude over 10 minutes (4 mice per group). Two-way ANOVA: *P < 0.05.