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. 2014 Dec 4;29(4):1185–1197. doi: 10.1096/fj.14-260570

Figure 1.

Figure 1.

Pon3KO mice exhibit increased atherosclerosis, premature death, increased hepatic cholesterol accumulation, and altered hepatic gene expression when fed a CC diet. Three-month-old WT and Pon3KO mice were maintained on a CC diet for 16 wk before (A) atherosclerotic lesion at the aortic root region, (B) survival, (C) liver lipid content, (D) hepatic gene expression, and (E) hepatic Cyp7A1 protein levels were determined. CE, cholesterol ester; TC, total cholesterol; TG, triglyceride; UC, unesterified cholesterol. *P < 0.05; **P < 0.01; ***P < 0.001 between the 2 genotype groups.