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Gallstone formation is increased in Pon3KO mice fed the CC diet. WT and Pon3KO mice were maintained on the CC diet for 10 wk (A, C) or 2 wk (B) before (A) gallbladder bile composition (8 WT and 10 Pon3KO mice), (B) hepatic bile composition (6 WT and 6 Pon3KO mice), and (C) gallstone weight were determined. Symbols as in Fig. 1.
