Figure 6.

Increased obesity and impaired mitochondrial function in the white adipose tissues of Pon3KO mice. The 5.5-mo-old Pon3KO and WT mice were fed a Western diet for 10 wk before (A) body weight and (B) fat pad weight (expressed as percentage of body weight) were determined (n = 13 for each genotype). Retro, retroperitoneal. C) The average size of adipocytes of the gonadal fat pad is shown. Gonadal fat pads from 6 mice of each group were examined. The oxygen consumption rate of gonadal and subcutaneous fat pads was examined in the presence of (D) FCCP and (E) palmitate. F) OCR of differentiated white adipocytes derived from the Pon3KO and WT mice was examined at baseline and after the sequential injection of oligomycin, FCCP, and rotenone/myxothiazol. Symbols as in Fig. 1.