Table 2.

The number of deaths observed after single doses of TP-loaded nanoparticles and TP administered intravenously in mice for 14 days

Group	Dose (mg/kg)	Total number of mice	Number of deaths	Mortality (%)	LD50 (mg/kg)	95% credibility
TP	0.51	10	0	0	0.837	0.740–0.952
	0.64	10	2	20
	0.80	10	5	50
	1.00	10	6	60
	1.25	10	10	100
TP-loaded nanoparticles	0.80	10	0	0	1.364	1.219–1.540
	1.00	10	1	10
	1.25	10	4	40
	1.56	10	6	60
	1.95	10	10	100

Note: The LD₅₀ value of TP-loaded nanoparticles was 63% higher than that of TP.

Abbreviations: TP, triptolide; LD₅₀, lethal median dose.