Table 4.
Comparison of the COMT Val158Met genotype with the subcategories of HAMD17 scores according to the method of Seretti et al13 at baseline for the patients with major depressive disorder
| Seretti et al’s category (modified) | Subcategories of HAMD17 | Val/Val | Met carrier | P-value |
|---|---|---|---|---|
| Core symptom | 1. depressed mood, 2. feelings of guilt, 7. work and activities, 8. retardation: psychomotor, 10. anxiety (psychological), 13. somatic symptom general | 11.32±2.83 | 10.58±2.14 | 0.323 |
| Sleep | 4. insomnia early, 5. insomnia middle, 6. insomnia late | 2.89±0.46 | 2.96±1.59 | 0.840 |
| Activity | 7. work and activities, 8. retardation: psychomotor | 4.05±1.39 | 4.27±1.58 | 0.637 |
| Psychic anxiety | 9. agitation, 10. anxiety (psychological) | 2.68±1.34 | 2.31±1.16 | 0.318 |
| Somatic anxiety | 11. anxiety somatic, 12. somatic symptoms (gastrointestinal), 13. somatic symptoms general | 3.74±1.59 | 3.81±1.16 | 0.866 |
| Delusion | 2. feelings of guilt, 15. hypochondriasis | 2.68±1.34 | 2.35±1.06 | 0.348 |
Notes: P-values calculated using Students t-test. Data are presented as mean ± standard deviation.
Abbreviation: HAMD17, 17-item Hamilton Rating Scale for Depression; COMT, catechol-O-methyltransferase; Val, valine; Met, methionine.