Table 1.
Antiparasitic activity and cytotoxicity of SaFr1, the viability was determined by the colorimetric assay of MTT at 570 nm
| Compounds | IC 50 mμg/mL) (95% CI) | |||
|---|---|---|---|---|
| L. (L.) infantum promastigotes | L. (L.) infantum amastigotes | T. cruzi trypomastigotes | Macrophages cytotoxicity | |
| SaFr1 | 0.065 (0.051-0.081) | NA | 2.755 (2.235-3.396) | 0.278 (0.231-0.336) |
| Miltefosine | 27.26 (25.63-28.97) | 17.80 (11.57-24.57) | – | 122.0 (94.78-157.00) |
| Glucantime | NA | 25.0 (24.40-25.63) | – | >200 |
| Benznidazole | – | – | 114.68 (105.69-124.49) | 469.93 (414.98-532.18) |
IC50: 50% inhibitory concentration; 95% CI: 95% confidence interval; NA: not active.