Table 3.

Adjusted hazards ratios for outcomes on dialysis therapy, patients with ADPKD (n = 23,772)

Group	Reference	Death	Listing	Transplant
		27.9 %/4.3 years	53 %/1.8 years	35.7 %/2.9 years
Initial RRT 2006-2010	2001-2005	0.86 (0.81-0.92)	0.99 (0.95-1.04)a	0.86 (0.82-0.9)
Age 40-64 yrs.	< 40	1.76 (1.52-2.03)	0.88 (0.81-0.94)	0.92 (0.86-1)b
Age ≥ 65 yrs.	< 40	7.19 (6.22-8.31)	0.21 (0.19-0.23)	0.26 (0.23-0.29)
Female sex	Male	0.86 (0.81-0.9)	0.96 (0.92-1.01)a	0.93 (0.89-0.97)c
African American race	White	1 (0.93-1.08)a	0.77 (0.71-0.82)	0.45 (0.41-0.48)
Other race	White	0.7 (0.61-0.81)	1.06 (0.95-1.19)a	0.68 (0.61-0.77)
Hispanic ethnicity	Non-Hispanic	0.73 (0.66-0.81)	0.96 (0.89-1.03)a	0.54 (0.5-0.59)
Ischemic heart disease	Absent	1.69 (1.58-1.81)	0.61 (0.55-0.67)	0.58 (0.53-0.65)
Diabetes	Absent	1.52 (1.4-1.64)	0.69 (0.63-0.76)	0.53 (0.48-0.59)
Peritoneal dialysis	Hemodialysis	0.66 (0.61-0.72)	1.34 (1.26-1.42)	1.21 (1.15-1.28)
Preemptive transplant
Living donor	Hemodialysis	0.13 (0.10-0.16)c	-	-
Deceased donor	Hemodialysis	0.21 (0.16-0.29)c	-	-
Nephrology care ≤ 12 mo.d	≥12	1.09 (1.02-1.16)c	0.87 (0.82-0.92)	0.69 (0.65-0.73)
eGFR > 15 mL/min/1.73 m2	≤15	1.76 (1.57-1.98)	0.74 (0.65-0.85)	0.73 (0.63-0.84)
BMI ≥ 30 kg/m2	< 30	0.84 (0.79-0.89)	0.97 (0.92-1.02)a	0.8 (0.76-0.85)
Albumin < 3.5 g/dL	≥ 3.5	1.86 (1.76-1.97)	0.67 (0.63-0.72)	0.68 (0.64-0.73)
Hemoglobin ≥ 9 g/dL	< 9.0	0.87 (0.82-0.92)	1.22 (1.15-1.29)	1.19 (1.13-1.26)

Note: Hazards ratios are adjusted for age, sex, race, and ethnicity and are presented with 95% confidence intervals in parentheses. P ≥ 0.05 unless otherwise indicated. ADPKD, autosomal dominant polycystic kidney disease; BMI, body mass index; eGFR, estimated glomerular filtration rate; RRT, renal replacement therapy.

^a0.01 ≤P value < 0.05.

^b0.001 ≤P value< 0.01.

^cP value < 0.001.

^dInformation available for 58.9% of the cohort (n = 14,002).