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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2015 Feb 12;35(4):877–887. doi: 10.1161/ATVBAHA.114.304802

Fig 7. Schematic representation describing the role of TRPM2 in mediating VEGF-induced angiogenesis.

Fig 7

VEGF induced the association of TRPM2 with c-Src on VE-cadherin forming a signaling complex leading to TRPM2 mediated Ca2+ influx and c-Src phosphorylation on active Y416 site. Activation of c-Src phosphorylated VE-cadherin on Y658 and Y731 induced AJ disassembly and EC migration resulting in activation of angiogenesis program.