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. Author manuscript; available in PMC: 2015 Apr 14.
Published in final edited form as: Trends Neurosci. 2014 Feb 7;37(3):169–177. doi: 10.1016/j.tins.2014.01.003

Figure 2. MGE-sourced interneurons survive and synaptically integrate upon transplantation into a variety of CNS tissues.

Figure 2

Interneurons sourced from embryonic mouse MGE are amenable to transplantation. GFP+ MGE tissue is dissected out, and resuspended as single cells (a) then injected into the desired host tissue (b). Various adult and neonatal tissues have been proven to be permissive to support transplanted interneurons derived from GFP+ MGE. These cells migrate away from the transplant core and many are able to integrate within the host circuitry (c and d, MGE derived interneurons = green, host cells = grey). Transplanted interneurons mature into GABAergic cells competent to release GABA upon depolarization along with trophic factors that can influence the downstream activity of host cells via opening GABA selective ion permeable channels (e).