Table 2. Prevalence of HPV by Bethesda Classification by cytology.
| HPV types | Normal | ASCUS | LSIL | HSIL | ICC | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HIGH-RISK | Type | Sample Size, N | # Cases (studies) | Prevalence (%) (95%CI) | Sample Size, N | # Cases (studies) | Prevalence (%) (95%CI) | Sample Size, N | # Cases (studies) | Prevalence (%) (95%CI) | Sample Size, N | # Cases (studies) | Prevalence (%)(95%CI) | Sample Size, N | # Cases (studies) | Prevalence (%) (95%CI) |
| hpv16 | 17273 | 766 (42) | 4.4 (4.1–4.7) | 1019 | 122 (15) | 12 (10.0–14.1) | 1444 | 213 (23) | 14.5 (12.8–16.4) | 1571 | 504 (33) | 31.2 (28.9–33.5) | 4067 | 2078 (43) | 49.7 (48.2–51.2) | |
| hpv18 | 17273 | 491 (42) | 2.8 (2.6–3.1) | 1019 | 45 (15) | 4.4 (3.2–5.9) | 1444 | 146 (23) | 10.0 (8.5–11.6) | 1571 | 224 (33) | 13.9 (12.2–15.6) | 4067 | 751 (43) | 18.0 (16.8–19.2) | |
| hpv31 | 17273 | 329 (42) | 1.9 (1.7–2.1) | 1019 | 27 (15) | 2.6 (1.8–3.8) | 1444 | 67 (23) | 4.6 (3.6–5.8) | 1571 | 133 (33) | 8.2 (6.9–9.7) | 3845 | 104 (38) | 2.7 (2.2–3.3) | |
| hpv33 | 17273 | 273 (42) | 1.6 (1.4–1.8) | 1019 | 24 (15) | 2.4 (1.5–3.5) | 1444 | 73 (23) | 5.0 (3.9–6.2) | 1571 | 167 (33) | 10.3 (8.9–11.9) | 3540 | 167 (32) | 4.7 (4–5.5) | |
| hpv35 | 17105 | 511 (40) | 3.0 (2.7–3.3) | 1019 | 40 (15) | 3.9 (2.8–5.3) | 1444 | 164 (23) | 11.2 (9.6–12.9) | 1571 | 216 (33) | 13.4 (11.7–15.1) | 3619 | 198 (31) | 5.5 (4.8–6.3) | |
| hpv39 | 16128 | 205 (38) | 1.3 (1.1–1.5) | 964 | 28 (13) | 2.9 (1.9–4.2) | 1386 | 50 (20) | 3.6 (2.7–4.7) | 1510 | 55 (31) | 3.4 (2.6–4.4) | 3605 | 39 (36) | 1.1 (0.8–1.5) | |
| hpv45 | 17008 | 339 (40) | 2.0 (1.8–2.2) | 1010 | 37 (14) | 3.7 (2.6–5.0) | 1444 | 76 (22) | 5.2 (4.1–6.5) | 1445 | 104 (31) | 6.4 (5.3–7.7) | 4067 | 408 (42) | 10.0 (9.1–10.9) | |
| hpv51 | 17105 | 363 (40) | 2.1 (1.9–2.3) | 1019 | 31 (15) | 3 (2.1–4.3) | 1444 | 84 (23) | 5.7 (4.6–7.0) | 1571 | 92 (33) | 5.7 (4.6–6.9) | 3619 | 76 (32) | 2.1 (1.7–2.6) | |
| hpv52 | 16128 | 518 (38) | 3.2 (2.9–3.5) | 964 | 66 (13) | 6.8 (5.3–8.6) | 1428 | 148 (21) | 10.4 (8.8–12.1) | 1438 | 191 (30) | 11.8 (10.3–13.5) | 3427 | 146 (30) | 4.3 (3.6–5) | |
| hpv56 | 16128 | 253 (38) | 1.6 (1.4–1.8) | 964 | 22 (13) | 2.3 (1.4–3.4) | 1386 | 89 (20) | 6.4 (5.2–7.8) | 1415 | 72 (29) | 4.5 (3.5–5.6) | 3427 | 33 (30) | 1.0 (0.7–1.3) | |
| hpv58 | 16128 | 421 (38) | 2.6 (2.4–2.9) | 964 | 26 (13) | 2.7 (1.8–3.9) | 1428 | 89 (21) | 6.2 (5.0–7.6) | 1438 | 183 (30) | 11.3 (9.8–13) | 3427 | 83 (30) | 2.4 (1.9–3) | |
| hpv59 | 16128 | 192 (40) | 1.2 (1–1.4) | 964 | 19 (13) | 2 (1.2–3.1) | 1386 | 54 (20) | 3.9 (2.9–5.1) | 1415 | 35 (29) | 2.2 (1.5–3) | 3618 | 27 (36) | 0.7 (0.5–1.1) | |
| LOW-RISK | hpv6 | 17273 | 132 (42) | 0.8 (0.6–0.9) | 1019 | 12 (15) | 1.2 (0.6–2.0) | 1444 | 38 (23) | 2.6 (1.8–3.5) | 1571 | 39 (33) | 2.4 (1.7–3.3) | 4181 | 42 (43) | 1 (0.7–1.4) |
| hpv11 | 13680 | 59 (36) | 0.4 (0.3–0.6) | 964 | 5 (13) | 0.5 (0.2–1.2) | 1230 | 17 (20) | 1.4 (0.8–2.2) | 1336 | 18 (29) | 1.1 (0.7–1.8) | 2919 | 12 (31) | 0.4 (0.2–0.7) | |
| hpv53 | 14664 | 258 (36) | 1.8 (1.6–2.0) | 964 | 28 (13) | 2.9 (1.9–4.2) | 1188 | 85 (19) | 7.2 (5.8–8.8) | 1232 | 92 (28) | 5.6 (4.6–6.9) | 3129 | 19 (28) | 0.6 (0.4–0.9) | |
| hpv54 | 13119 | 99 (31) | 0.8 (0.6–0.9) | 964 | 25 (13) | 2.6 (1.7–3.8) | 981 | 30 (17) | 3.1 (2.1–4.3) | 1085 | 34 (25) | 2.1 (1.5–2.9) | 2233 | 1 (20) | 0 (0–0.2) | |
| hpv66 | 14797 | 201 (36) | 1.4 (1.2–1.6) | 964 | 28 (13) | 2.9 (1.9–4.2) | 1188 | 60 (19) | 5.1 (3.9–6.5) | 1232 | 86 (28) | 5.3 (4.3–6.5) | 3209 | 23 (27) | 0.7 (0.5–1.1) | |
| hpv68 | 15819 | 245 (37) | 1.5 (1.4–1.8) | 964 | 19 (13) | 2 (1.2–3.1) | 1428 | 50 (21) | 3.5 (2.6–4.6) | 1438 | 62 (30) | 3.8 (3.0–4.9) | 2051 | 30 (21) | 1.5 (1–2.1) | |
| hpv70 | 13098 | 108 (30) | 0.8 (0.7–1) | 885 | 9 (12) | 1 (0.5–1.9) | 1002 | 31 (18) | 3.1 (2.1–4.4) | 833 | 22 (22) | 1.4 (0.9–2.1) | 2525 | 5 (27) | 0.2 (0.1–0.5) | |
| hpv82 | 11558 | 20 (27) | 0.2 (0.1–0.3) | 964 | 2 (13) | 0.2 (0–0.7) | 821 | 11 (16) | 1.3 (0.7–2.4) | 1013 | 9 (24) | 0.6 (0.3–1.1) | 1485 | 0 (21) | 0 (0–0.2) | |
| hpvmult* | 15157 | 1399 (37) | 9.2 (8.8–9.7) | 897 | 474 (14) | 20.6 (18–23.4) | 1054 | 475(20) | 44.6 (41.6–47.7) | 1519 | 1371 (29) | 38.5 (36.1–40.9) | 3553 | 545 (33) | 15.3 (14.2–16.6) | |
| anyhpv | 17273 | 5074 (42) | 29.3 (28.6–30.0) | 1019 | 185 (15) | 46.5 (43.4–49.6) | 1444 | 1087(23) | 74.2 (71.9–76.4) | 1571 | 622 (33) | 84.8 (82.9–86.5) | 4067 | 3741 (43) | 89.5 (88.5–90.4) | |
hpvmult*—Multiple HPV genotypes.