Table 1.
Baseline Characteristics According to the Tertile of DWI Lesion Volume
| DWI Lesion Volume, cc | |||||
|---|---|---|---|---|---|
| Overall (n=139) | <8 (n=46) | 8–32 (n=47) | >32 (n=46) | P for Trend | |
| DWI volume, cc, median (IQR) | 14 (5–43) | 3 (1–5) | 14 (10–20) | 60 (43–104) | NA |
| Age, y, mean (SD) | 69.8 (17.6) | 76.2 (13.4) | 67.1 (17.8) | 66.2 (19.6) | 0.006 |
| Men | 65 (46.8) | 21 (45.6) | 26 (55.3) | 18 (39.1) | 0.53 |
| Medical history | |||||
| Hypertension | 69 (50.4) | 26 (56.5) | 19 (40.4) | 25 (54.4) | 0.84 |
| Diabetes mellitus | 17 (12.2) | 6 (13.0) | 4 (8.5) | 7 (15.2) | 0.75 |
| Hypercholesterolemia | 35 (25.6) | 13 (28.9) | 10 (21.3) | 12 (26.7) | 0.81 |
| Current or former smoker | 49 (35.3) | 19 (41.3) | 15 (31.9) | 15 (32.6) | 0.38 |
| Antithrombotic medications | 53 (38.1) | 20 (43.5) | 15 (31.9) | 18 (39.1) | 0.67 |
| Clinical measure | |||||
| Blood glucose, mg/dL, median (IQR) | 117 (101–146) | 122 (110–155) | 112 (95–133) | 124 (101–162) | 0.83 |
| SBP, mm Hg, mean (SD) | 148 (23) | 152 (20) | 146 (24) | 146 (23) | 0.27 |
| DBP, mm Hg, mean (SD) | 79 (14) | 80 (15) | 79 (13) | 80 (13) | 0.92 |
| NIHSS score, median (IQR) | 16 (10–21) | 12 (9–17) | 16 (10–22) | 18 (15–22) | <0.001 |
| Cardioembolism | 81 (58.3) | 27 (58.7) | 30 (63.8) | 24 (52.2) | 0.53 |
| ICA occlusion (isolated or tandem with MCA) | 41 (29.5) | 12 (26.1) | 10 (21.3) | 19 (41.3) | 0.11 |
| Time to MRI, min, median (IQR) | 110 (77–178) | 95 (73–135) | 120 (80–210) | 121 (85–190) | 0.11 |
| AIS treatment | |||||
| Combined IV/IA | 97 (69.8) | 40 (87.0) | 30 (63.8) | 27 (58.7) | 0.003 |
| IA alone | 42 (30.2) | 6 (13.0) | 17 (36.2) | 19 (41.3) | |
| Time to AIS treatment, min, median (IQR) | |||||
| Combined IV/IA | 132 (110–155) | 135 (102–157) | 128 (110–155) | 133 (110–154) | 0.82 |
| IA alone | 314 (260–350) | 260 (195–320) | 322 (309–370) | 300 (220–346) | 0.28 |
Data are presented as no. (%) unless otherwise indicated.
AIS indicates acute ischemic stroke; BP, blood pressure; DBP, diastolic BP; DWI, diffusion-weighted imaging; IA, intra-arterial; ICA, internal carotid artery; IQR, interquartile range; IV, intravenous; NA, not applicable; NIHSS, National Institutes of Health Stroke Scale; MCA, middle cerebral artery; and SBP, systolic BP.