Table 1.
Functional and mitochondria data in long-term follow-up groups.
| Parameter | Vehicle | OA | OA + Tempol | OA + AP |
|---|---|---|---|---|
| Plasma UA (μmol/L) | 44 ± 2 | 110 ± 27a | 117 ± 36a | 26 ± 6b |
| Systolic blood pressure (mmHg) | 125 ± 4 | 144 ± 7a | 121 ± 5b | 129 ± 8b |
| RPF (mL/min) | 3.7 ± 0.3 | 2.7 ± 0.4a | 4.4 ± 0.3ab | 4.1 ± 0.3b |
| RVR (mmHg/mL/min) | 19 ± 1 | 28 ± 5a | 15 ± 1b | 17 ± 3b |
|
| ||||
| Mitochondrial respiration malate/glutamate | ||||
| State 3 (ng AtO2/min/mg prot) | 83 ± 18 | 43 ± 13a | 149 ± 44ab | 114 ± 43b |
| State 4 (ng AtO2/min/mg prot) | 34 ± 6c | 30 ± 11c | 57 ± 21 | 37 ± 5c |
|
| ||||
| Mitochondrial respiration succinate/rotenone | ||||
| State 3 (ng AtO2/min/mg prot) | 170 ± 60 | 84 ± 36a | 238 ± 53b | 237 ± 60b |
| State 4 (ng AtO2/min/mg prot) | 70 ± 20 | 53 ± 25 | 87 ± 20b | 65 ± 14 |
Data are expressed as mean ± SD. RPF = renal plasma flow; RVR = renal vascular resistance. a P < 0.05 versus control; b P < 0.05 versus OA; c P < 0.05 versus Tempol.