Table 2.
Virus distribution (log VG/mg [log VG/µL for blood]; mean ± 1 SD) at terminal euthanasia (day 29 or 43) after multiple dosing in female rats
| Vehicle | Low-dose H1PV | Intermediate-dose H1PV | High-dose H1PV | Recovery vehicle | Recovery high-dose H1PV | ||
| Blood | Mean | LLOQ | 2.68 ± 0.64 | 3.53 ± 1.18 | 4.87± 0.85 | LLOQ | 1.66 ± 0.45 |
| N | 5 | 4 (3) | 5 (4) | 5 | 5 | 4 (2) | |
| Brain | Mean | LLOQ | LLOQ | 3.00 ± 0.24 | 4.04 ± 0.17 | LLOQ | 3.22 ± 0.20 |
| 5 | 5 | 5 | 5 | 5 | 4 | ||
| Lung | Mean | LLOQ | 3.56 ± 0.52 | 5.51 ± 0.35 | 6.84 ± | 2.52 | 4.34 ± 0.27 |
| n | 5 | 5 | 5 | 5 | 5 (4) | 4 (3) | |
| Liver | Mean | LLOQ | 6.28 ± 0.14 | 7.11 ± 0.11 | 7.83 ± 0.15 | 2.44 ± 0.04 | 6.16 ± 0.29 |
| n | 5 | 5 | 5 | 5 (3) | 5 (2) | 4 | |
| Spleen | Mean | LLOQ | 7.11 ± 0.14 | 7.43 ± 0.09 | 8.09 ± 0.16 | LLOQ | 7.04 ± 0.29 |
| n | 5 | 5 (4) | 5 | 5 | 5 | 4 | |
| Kidney | Mean | LLOQ | 3.29 ± 0.06 | 4.73 ± 0.40 | 5.53 ± 0.15 | LLOQ | 4.71 ± 0.40 |
| n | 5 | 5 (4) | 5 | 5 | 5 | 4 | |
| Heart | Mean | LLOQ | LLOQ | 2.95 ± 0.15 | 4.42 ± 0.32 | LLOQ | 2.51 ± 0.03 |
| n | 5 | 5 | 5 | 5 | 5 | 4(2) | |
| Pancreas | Mean | 2.75 | 2.94 ± 0.56 | 3.25 ± 0.76 | 6.54 ± 0.22 | LLOQ | 3.90 ± 0.13 |
| n | 5 (1) | 5 (4) | 5 (4) | 5 | 5 | 4 (2) | |
| Mammary | Mean | 3.32 | 3.35 ± 0.20 | 3.92 ± 0.12 | 5.37 ± 1.03 | 4.04 | 3.54 |
| n | 5 (1) | 5 (2) | 5 | 5 | 5 (1) | 4 (1) | |
| Bone marrow | Mean | 3.23 | 3.80 ± 0.73 | 5.88 ± 0.17 | 6.30 ± 1.16 | LLOQ | 4.76 ± 0.33 |
| n | 5 (1) | 5 (4) | 5 (4) | 5 (4) | 5 | 4 |
The number of analyzed samples is given; the number in parentheses is the number of samples included in the calculation of mean values and standard deviations. Values below the lower limit of quantification (LLOQ) were not included in the calculation.