Table 2.
Concentration of H1PV ((log mean ± 1 SD; no. of VG/µg genomic DNA) in tissues after single intravenous or intracerebral administration of Wistar rats with 7.96 × 107pfu
| IC 6 h | IC 48 h | IC 14 d | IV 6 h | IV 48 h | IV 14 d | ||
| Male | Brain | 6.64 ± 0.58 | 6.26 ± 1.10 | 4.99 ± 1.13 | 4.50 ± 0.67 | 3.67 ± 0.31 | 3.05 ± 0.56 |
| 6 (5)a | 6 (5) | 6 | 6 | 6 | 6 (5) | ||
| Heart | 4.99 ± 0.62 | 4.17 ± 8.00 | 3.29 | 4.99 ± 0.91 | 4.29 ± 0.77 | 3.62 ± 0.11 | |
| 6 | 6 (5) | 6 (1) | 6 | 6 (5) | 6 (3) | ||
| Lung | 5.49 ± 0.86 | 5.88 ± 1.05 | 5.71 ± 1.15 | 6.16 ± 1.30 | 6.36 ± 1.51 | 5.88 ± 0.86 | |
| 6 (3) | 6 (5) | 6 | 6 (3) | 6 | 6 (5) | ||
| Liver | 6.90 ± 0.62 | 6.25 ± 1.04 | 4.83 ± 0.53 | 7.21 ± 0.45 | 6.50 ± 0.85 | 5.09 ± 0.99 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Spleen | 6.79 ± 0.45 | 6.31 ± 1.02 | 5.62 ± 0.70 | 7.07 ± 0.46 | 6.78 ± 0.65 | 5.66 ± 0.87 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Kidney | 5.80 ± 0.53 | 5.01 ± 0.97 | 4.44 ± 0.22 | 6.06 ± 0.66 | 5.58 ± 0.64 | 4.48 ± 0.94 | |
| 6 | 6 | 6 (5) | 6 | 6 | 6 (5) | ||
| Mandibular lymph node | 5.82 ± 1.03 | 5.16 ± 1.36 | 3.42 ± 1.34 | 3.96 ± 0.46 | 4.26 ± 0.96 | 2.66 ± 1.01 | |
| 6 | 6 (5) | 6 | 6 | 6 | 6 (4) | ||
| Mesenteric lymph node | 4.49 ± 0.95 | 4.13 ± 1.24 | 3.74 ± 1.17 | 5.41 ± 0.39 | 5.12 ± 0.87 | 3.79 ± 0.81 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Pancreas | 5.30 ± 0.53 | 4.65 ± 0.45 | 4.88 ± 0.65 | 5.38 ± 0.72 | 4.71 ± 0.54 | 3.77 ± 0.71 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Prostate | 4.39 ± 0.52 | 3.81 ± 0.76 | 4.05 ± 0.85 | 4.47 ± 0.43 | 4.42 ± 0.32 | 3.43 ± 0.42 | |
| 6 | 6 (4) | 6 (5) | 6 | 6 (4) | 6 (3) | ||
| Mammary | 5.1 ± 0.15 | 4.27 ± 0.58 | 5.54 | 4.97 ± 0.45 | 5.92 ± 0.78 | 3.83 | |
| 4 (3) | 6 (4) | 6 (1) | 5 | 6 (2) | 5 (1) | ||
| Bone marrow | 4.95 ± 0.56 | 4.49 ± 0.92 | 2.97 ± 0.69 | 5.05 ± 0.74 | 4.61 ± 0.71 | 3.10 ± 0.68 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Female | Brain | 6.78 ± 0.61 | 5.92 ± 1.12 | 6.26 ± 0.48 | 4.47 ± 0.33 | 3.48 ± 0.35 | 2.55 ± 0.79 |
| 6 (5) | 6 (4) | 6 | 6 | 6 | 6 (4) | ||
| Heart | 4.97 ± 0.60 | 4.13 ± 0.54 | 3.12 ± 0.19 | 4.48 ± 0.76 | 3.61 ± 0.44 | LLOQ | |
| 6 | 6 (4) | 6 (4) | 6 | 6 | 6 | ||
| Lung | 4.82 ± 0.87 | 4.91 ± 1.35 | 4.93 ± 0.64 | 4.20 ± 0.91 | 4.71 ± 0.23 | 4.10 ± 0.64 | |
| 6 (5) | 6 (5) | 6 (5) | 6 (4) | 6 | 6 | ||
| Liver | 7.35 ± 0.49 | 6.10 ± 1.58 | 5.70 ± 0.37 | 7.14 ± 0.71 | 6.20 ± 0.25 | 4.38 ± 0.22 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Spleen | 7.14 ± 0.60 | 6.01 ± 1.56 | 6.43 ± 0.26 | 6.76 ± 0.63 | 6.20 ± 0.27 | 5.84 ± 0.55 | |
| 6 | 6 | 6 | 6 | 6 | 6 | ||
| Kidney | 6.19 ± 0.74 | 5.75 ± 0.39 | 4.89 ± 0.16 | 6.18 ± 0.74 | 5.04 ± 0.28 | 3.67 ± 0.28 | |
| 6 (5) | 6 (4) | 6 | 6 | 6 | 6 (4) | ||
| Mandibular lymph node | 6.30 ± 0.92 | 4.61 ± 1.57 | 3.93 ± 1.73 | 4.26 ± 0.74 | 3.56 ± 0.92 | 4.36 ± 0.45 | |
| 6 | 6 | 6 | 6 | 6 | 6 (2) | ||
| Mesenteric lymph node | 4.99 ± 0.64 | 3.73 ± 1.30 | 4.66 ± 0.80 | 4.41 ± 0.78 | 3.75 ± 0.76 | 4.20 ± 0.80 | |
| 6 | 6 | 6 | 6 | 6 | 5 | ||
| Pancreas | 5.39 ± 0.56 | 4.80 ± 0.46 | 4.51 ± 0.33 | 5.26 ± 0.71 | 5.03 ± 0.93 | 4.17 ± 1.12 | |
| 6 | 6 | 6 | 6 | 6 | 5 | ||
| Mammary | 4.81 ± 0.66 | 4.53 ± 0.73 | 4.46 | 5.33 ± 0.40 | 4.12 ± 0.70 | LLOQ | |
| 6 | 6 (2) | 6 (1) | 6 (5) | 6 (2) | 6 | ||
| Bone marrow | 5.75 ± 0.41 | 4.40 ± 1.24 | 3.91 ± 0.55 | 5.28 ± 0.76 | 4.53 ± 0.42 | 2.90 ± 0.50 | |
| 6 | 6 | 6 | 6 | 6 | 6 |
LLOQ, lower limit of quantification; VG, viral genomes
a
No, of samples analyzed (no. of results included in calculation of mean values and standard deviations); values below the LLOQ or above the upper limit of quantification were not included in the calculation.