Table 3.
Excretion (log mean ± 1 SD) of H1PV in feces, urine, and saliva of rats after single administration of 7.96 × 107pfu
| Time | Male |
Female |
|||||
| Feces (VG/mg) | Urine (VG/µL) | Saliva (VG/swab) | Feces (VG/mg) | Urine (VG/µL) | Saliva (VG/swab) | ||
| Intracerebral | 0 h | LLOQ | LLOQ | 5.14 ± 0.60 | 1.66 ± 0.68 | LLOQ | 4.28 |
| 6 h | 3.11 ± 1.69 | 1.89 ± 0.24 | 4.32 ± 0.13 | 2.42 ± 1.07 | 2.10 ± 0.14 | 4.48 | |
| 48 h | 3.38 ± 0.56 | 2.02 ± 0.80 | LLOQ | 3.95 ± 0.38 | 2.10 ± 0.85 | LLOQ | |
| 4 d | 2.84 ± 0.35 | 2.23 ± 0.89 | 4.59 ± 0.61 | 2.80 ± 0.35 | 1.98 ± 0.79 | 5.48 ± 0.49 | |
| 7 d | 2.57 ± 0.26 | 2.19 ± 0.86 | LLOQ | 2.78 ± 0.05 | 1.93 ± 0.74 | LLOQ | |
| 10 d | 2.22 ± 0.57 | 2.01 | 4.10 | 2.75 ± 0.42 | 2.27 ± 0.66 | 4.27 | |
| 14 d | 2.38 ± 0.48 | LLOQ | 4.18 | 2.11 ± 0.22 | LLOQ | LLOQ | |
| Intravenous | 0 h | LLOQ | LLOQ | 4.46 ± 0.35 | LLOQ | LLOQ | LLOQ |
| 6 h | 3.03 ± 1.24 | 1.43 | LLOQ | 1.50 ± 0.49 | 2.01 ± 0.55 | 4.41 ± 0.24 | |
| 48 h | 3.26 ± 0.80 | 2.46 ± 1.34 | LLOQ | 2.81 ± 0.29 | 2.04 ± 0.19 | LLOQ | |
| 4 d | 3.00 ± 0.95 | 1.62 ± 0.18 | 5.05 | 2.21 ± 0.27 | 2.28 ± 0.65 | LLOQ | |
| 7 d | 2.96 ± 1.06 | LLOQ | LLOQ | 2.59 ± 0.26 | 1.93 | LLOQ | |
| 10 d | 2.50 ± 1.00 | LLOQ | LLOQ | 2.07 ± 0.54 | LLOQ | 5.05 | |
| 14 d | 2.51 ± 0.75 | LLOQ | LLOQ | 2.11 ± 0.36 | LLOQ | LLOQ | |
LLOQ, lower limit of quantification; VG, viral genomes