Table 4.
No. of injection-site–associated histologic lesions after single intracerebral injection of 8 rats with H1PV at 3 dose levels
| Vehicle (n = 5)a | 7.96 × 105 pfu (n = 8)a | 7.96 × 106 pfu (n = 7)a | 7.96 × 107 pfu (n = 7)a | |
| Haemorrhage | ||||
| minimal | 2 | 1 | 3 | 2 |
| mild | 0 | 3 | 3 | 4 |
| moderate | 2 | 3 | 0 | 1 |
| marked | 0 | 1 | 1 | 0 |
| total | 4 | 8 | 7 | 7 |
| Necrosis or malacia | ||||
| minimal | 3 | 3 | 2 | 4 |
| mild | 1 | 4 | 4 | 2 |
| moderate | 1 | 0 | 1 | 1 |
| marked | 0 | 1 | 0 | 0 |
| total | 5 | 8 | 7 | 7 |
| Vasculitis or perivasculitis or both | ||||
| minimal | 2 | 6 | 5 | 1 |
| mild | 1 | 1 | 2 | 6 |
| total | 3 | 7 | 7 | 7 |
| Meningeal inflammatory infiltrates | ||||
| minimal | 2 | 1 | 4 | 3 |
| mild | 1 | 1 | 3 | 2 |
| moderate | 0 | 1 | 0 | 1 |
| marked | 0 | 0 | 0 | 1 |
| total | 3 | 3 | 7 | 7 |
a
No. of samples with histologically discernable injection site