Table 1.
Hemodynamic measurements
| Isoflurane | α-Chloralose | P | |
| Baseline | |||
| Heart rate (bpm) | 103 ± 4.0 | 60 ± 0.8a | <0.004 |
| SpO2 (%) | 95 ± 0.3 | 98 ± 0.2a | <0.004 |
| Respiratory rate (breaths/min) | 18 ± 0.5 | 16 ± 0.2a | <0.004 |
| End-tidal CO2 | 39 ± 0.6 | 42 ± 0.4a | <0.004 |
| Systolic blood pressure (mm Hg) | 107 ± 2.0 | 126 ± 1.0a | <0.004 |
| Diastolic blood pressure (mm Hg) | 70 ± 1.5 | 75 ± 1.0 | 0.004 |
| Mean arterial pressure (mm Hg) | 83 ± 1.7 | 96 ± 1.1a | <0.004 |
| Systolic pulmonary arterial pressure (mm Hg) | 33 ± 2.4 | 32 ± 0.9 | 0.704 |
| Diastolic pulmonary arterial pressure (mm Hg) | 18 ± 2.2 | 14 ± 0.7 | 0.011 |
| Clot induction | |||
| Heart rate (bpm) | 116 ± 3.0 | 63 ± 1.1a | <0.004 |
| SpO2 (%) | 95 ± 0.2 | 98 ± 0.3a | <0.004 |
| Respiratory rate (breaths/min) | 16 ± 0.6 | 16 ± 0.3 | 0.547 |
| End-tidal CO2 (mm Hg) | 32 ± 0.7 | 35 ± 0.6a | <0.004 |
| Systolic blood pressure (mm Hg) | 104 ± 1.4 | 121 ± 2.1a | <0.004 |
| Diastolic blood pressure (mm Hg) | 72 ± 1.0 | 73 ± 1.9 | 0.816 |
| Mean arterial pressure (mm Hg) | 84 ± 1.0 | 92 ± 2.1 | 0.020 |
| Systolic pulmonary arterial pressure (mm Hg) | 61 ± 1.9 | 53 ± 1.3a | <0.004 |
| Diastolic pulmonary arterial pressure (mm Hg) | 25 ± 3.0 | 27 ± 0.7 | 0.503 |
| Treatment | |||
| Heart rate (bpm) | 106 ± 3.0 | 61 ± 1.3a | <0.004 |
| SpO2 (%) | 95 ± 0.2 | 97 ± 1.0 | 0.158 |
| Respiratory rate (breaths/min) | 17 ± 0.4 | 16 ± 0.3 | 0.083 |
| End-tidal CO2 (mm Hg) | 34 ± 0.7 | 38 ± 0.6a | <0.004 |
| Systolic blood pressure (mm Hg) | 100 ± 1.0 | 131 ± 1.4a | <0.004 |
| Diastolic blood pressure (mm Hg) | 71 ± 1.3 | 78 ± 1.8 | 0.005 |
| Mean arterial pressure (mm Hg) | 82 ± 1.0 | 99 ± 1.8a | <0.004 |
| Systolic pulmonary arterial pressure (mm Hg) | 51 ± 0.8 | 51 ± 0.6 | 0.932 |
| Diastolic pulmonary arterial pressure (mm Hg) | 31 ± 1.1 | 25 ± 0.6a | <0.004 |
a
Value significantly different from that for isoflurane group.