Table 2.
Calculated measurements (mean ± SEM) of hemodynamics
| Isoflurane | α-Chloralose | P | |
| Baseline | |||
| Cardiac output (L/min) | 2.07 ± 0.13 | 1.66 ± 0.06a | <0.004 |
| Systemic vascular resistance (dyn × s/cm5) | 2348 ± 162 | 3690 ± 158a | <0.004 |
| Pulmonary vascular resistance (dyn × s/cm5) | 185 ± 43 | 450 ± 101 | 0.078 |
| RV:LV ratio | 0.80 ± 0.26 | 0.83 ± 0.03 | 0.843 |
| Clot induction | |||
| Cardiac output (L/min) | 1.70 ± 0.09 | 1.49 ± 0.04 | 0.020 |
| Systemic vascular resistance (dyn × s/cm5) | 2366 ± 204 | 3256 ± 160a | <0.004 |
| Pulmonary vascular resistance (dyn × s/cm5) | 907 ± 58 | 1617 ± 192 | 0.020 |
| RV:LV ratio | 1.32 ± 0.25 | 1.23 ± 0.07 | 0.669 |
| Treatment | |||
| Cardiac output (L/min) | 1.48 ± 0.09 | 1.75 ± 0.09 | 0.030 |
| Systemic vascular resistance (dyn × s/cm5) | 2334 ± 263 | 3096 ± 123 | 0.008 |
| Pulmonary vascular resistance (dyn × s/cm5) | 954 ± 160 | 1184 ± 133 | 0.305 |
| RV:LV ratio | 1.12 ± 0.14 | 1.02 ± 0.02 | 0.393 |
a
Value significantly different from that for isoflurane group.