Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 27;16(1):49. doi: 10.1186/s13059-015-0617-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Kuilman et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Copy number detection in the absence of a reference. (A) CopywriteR and onTarget methods were applied to WES data of melanoma PDX sample T99, either with or without C43 as a reference. Genome-wide copy number profiles are shown, with segmentation values (CBS) depicted in red. (B) CBS-derived segmentation values of the analysis in (A) are represented in a heatmap. (C) Segmentation values of all six melanoma PDX samples were treated as in (A) and (B), and the weighted Euclidian distances and Pearson correlation coefficients were calculated for every sample between the different methods. The means of those values across all samples are represented as clustered heatmaps.