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TIM-4+ macrophages trigger liver IRI in CD11b-DTR mice. Adoptive transfer of TIM-4 proficient (WT) but not TIM-4 deficient BMM (5×106 cells i.v. at -1h) recreated hepatocellular damage in CD11b-DTR mice (6h reperfusion after 90min ischemia), evidenced by (a) sALT levels; (b) hepatic histology (representative H&E; magnification x100 and x400); and (c) TNF-α, IL-1β, and IL-6 expression (*p<0.001). n=4-6/group.
