Table 3.
Summary table of the diagnostic accuracy of miR-155 for various cancers.
| Analyses | Sensitivity (95% CI) |
Specificity (95% CI) |
DOR (95% CI) |
Positive LR (95% CI) |
Negative LR (95% CI) |
AUC (95% CI) |
|---|---|---|---|---|---|---|
| MicroRNA profile | ||||||
| Single miR-155 | 0.82 (0.73–0.88) | 0.77 (0.70–0.83) | 15.34 (7.32–32.17) | 3.56 (2.55–4.95) | 0.23 (0.14–0.37) | 0.85 |
| Paneled miR-155 | 0.76 (0.68–0.82) | 0.82 (0.77–0.86) | 14.27 (7.98–25.53) | 4.23 (3.12–5.75) | 0.30 (0.22–0.40) | 0.86 |
| Sample types | ||||||
| Plasma-based | 0.74 (0.58–0.71) | 0.70 (0.63–0.76) | 5.54 (2.79–11.03) | 2.02 (1.65–2.48) | 0.41 (0.27–0.63) | 0.73 |
| Serum-based | 0.78 (0.74–0.82) | 0.77 (0.71–0.82) | 15.61 (7.03–34.67) | 3.47 (2.40–5.02) | 0.23 (0.13–0.41) | 0.87 |
| Ethnicity | ||||||
| Asian | 0.72 (0.68–0.76) | 0.72 (0.68–0.76) | 8.03 (4.82–13.38) | 2.68 (2.07–3.46) | 0.38 (0.29–0.50) | 0.81 |
| Caucasian | 0.94 (0.89–0.97) | 0.79 (0.69–0.87) | 61.93 (23.00–166.75) | 5.79 (1.51–22.24) | 0.08 (0.04–0.15) | 0.96 |
| Overall | 0.79 (0.73–0.84) | 0.79 (0.75–0.84) | 14.62 (9.10–23.48) | 3.86 (3.05–4.90) | 0.26 (0.20–0.35) | 0.86 |
| Outliers excluded | 0.84 (0.74–0.90) | 0.76 (0.68–0.83) | 16.41 (3.32–36.77) | 3.54 (2.49–5.05) | 0.21 (0.13–0.36) | 0.86 |
CI: confidence interval; LR: likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve.