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. Author manuscript; available in PMC: 2016 May 5.
Published in final edited form as: Eur J Pharmacol. 2015 Feb 25;754:125–133. doi: 10.1016/j.ejphar.2015.02.027

Fig. 2.

Fig. 2

Effect of dexmedetomidine (Dex) on quantitative sensory testing in BERK mice. Data are shown as means±S.E.M. and down arrows indicate administration of dexmedetomidine or vehicle. The unit of measurement of current threshold is “Unit” (U), which corresponds to 100 times the amperage that elicited vocalization (one current threshold unit equates to 0.01 mAmperes). A. BERK sickle mice had significantly higher hot plate latencies at 30 and 60 min after dexmedetomidine (50 and 100 µg/kg combined) compared to vehicle injections (both, P<0.001). B. BERK sickle mice also had significantly higher 250 Hz current thresholds at 30 (P=0.006) and 60 min (P<0.001) after dexmedetomidine (50 and 100 µg/kg combined) compared to vehicle injections. C. C57BL/6J, here used as controls for BERK sickle mice, also had significantly higher hot plate latencies at 30 (P<0.001) and 60 min (P=0.002) after dexmedetomidine (50 and 100 µg/kg combined) compared to vehicle injections. D. Overall, C57BL/6J mice had significantly higher 5 Hz current thresholds over 30 and 60 min after dexmedetomidine compared to vehicle injections (P=0.012).