Table 3. Association Of Ulceration With MSS Adjusted For Factors Known To Be Associated With Inflammation.
All given hazard ratios are for the association of ulceration with melanoma specific survival in the same subset of cases from the Leeds Melanoma Cohort, adjusted for different additional variables associated with inflammation.
| Adjusted for age and sex (n=1530) |
Adjusted for age, sex and Breslow (n=1518) |
|||
|---|---|---|---|---|
| Ulceration HR (95% CI) |
p-value | Ulceration HR (95% CI) |
p-value | |
| Ulceration only | 3.23 (2.48–4.21) | <0.001 | 2.03 (1.50–2.75) | <0.001 |
| +Vit D* | 3.15 (2.41–4.11) | <0.001 | 2.05 (1.51–2.78) | <0.001 |
| +BMI | 3.23 (2.48–4.21) | <0.001 | 2.01 (1.49–2.73) | <0.001 |
| +NSAID | 3.20 (2.46–4.18) | <0.001 | 2.02 (1.49–2.75) | <0.001 |
| +Aspirin Duration | 3.23 (2.48–4.21) | <0.001 | 2.03 (1.50–2.75) | <0.001 |
| +Diabetes | 3.23 (2.48–4.21) | <0.001 | 2.04 (1.50–2.77) | <0.001 |
| +Still smoke | 3.16 (2.42–4.12) | <0.001 | 2.01 (1.48–2.72) | <0.001 |
| +Duration smoked | 3.15 (2.42–4.11) | <0.001 | 2.03 (1.49–2.75) | <0.001 |
| +Vit D, duration smoked | 3.07 (2.35–4.01) | <0.001 | 2.04 (1.50–2.77) | <0.001 |
| +Vit D, duration smoked, NSAID use | 3.05 (2.33–3.98) | <0.001 | 2.03 (1.50–2.76) | <0.001 |
| +Vit D, duration smoked, NSAID use, diabetes | 3.05 (2.33–3.98) | <0.001 | 2.04 (1.50–2.77) | <0.001 |
| +Vit D, duration smoked, NSAID use, BMI | 3.05 (2.33–3.98) | <0.001 | 2.02 (1.48–2.74) | <0.001 |