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| IC50, μM | ||||
|---|---|---|---|---|
| Ligand | BRS3 | GRPR | NMBR | NCI-H727 |
| BA1 | 0.006 ± .001 | 0.0004 ± .0001 | 0.0025 ± .0003 | 0.004 ± .001 |
| EMY-98 | >100 | >100 | >100 | >100 |
| GRP | >10 | 0.0003 ± 0.0001 | 0.150 ± 23 | >10 |
| ML-18 | 4.8 ± 0.6 | 16 ± 2 | >100 | 6.4 ± 1.1 |
| NMB | >10 | 0.060 ± .008 | 0.0007 ± .0001 | >10 |
The mean IC50 ± S.D. of 3 determinations is indicated to inhibit specific 125I-BA1 binding to NCI-H727 lung cancer cells or cells transfected with BRS-3, GRPR or NMBR.
