Table 1. Gene Ontology (GO) terms associated with the implicated network.

GO ID	Ontology	Term	P-value
GO:0045202	CC	Synapse	3×10−7
GO:0016568	BP	chromatin modification	6×10−6
GO:0051015	MF	actin filament binding	7×10−6
GO:0005262	MF	calcium channel activity	1×10−5
GO:0031252	CC	cell leading edge	2×10−5
GO:0004386	MF	helicase activity	3×10−5
GO:0015629	CC	actin cytoskeleton	6×10−5
GO:0030036	BP	actin cytoskeleton organization	7×10−5
GO:0016887	MF	ATPase activity	7×10−5
GO:0005913	CC	cell-cell adherens junction	8×10−5
GO:0045211	CC	postsynaptic membrane	8×10−5
GO:0044456	CC	synapse part	0.0001
GO:0007611	BP	learning or memory	0.0001
GO:0030029	BP	actin filament-based process	0.0001
GO:0005938	CC	cell cortex	0.0001
GO:0005911	CC	cell-cell junction	0.0002
GO:0014069	CC	postsynaptic density	0.002
GO:0043005	CC	neuron projection	0.004
GO:0030425	CC	Dendrite	0.004

Gene Ontology (GO) terms enriched in the implicated network (Fig. 1), as identified by DAVID (david.abcc.ncifcrf.gov). P-values shown in the table were corrected for multiple hypotheses testing using the Benjamini-Hochberg procedure in DAVID. The ontology column indicates GO domain: BP for biological process, MF for molecular function, and CC for cellular component. Non-specific terms, i.e. terms associated with more than 400 human genes, are not shown. For a list of GO terms associated with each network cluster see Supplementary Table S3. The enrichment calculations were performed using the default background set of all human genes; similar enrichment results were also obtained using brain-expressed genes as background (see Supplementary Table S4).