Table 10.

SAR study on arylamides.

Compound	X	n	R1	R2	IC50 (μM)
a1	N	0	H	H	38.86 ± 1.35
a2	N	0	4-CH3	H	16.64 ± 0.49
a3	N	0	4-CH3	3-CF3	6.26 ± 0.33
a4	N	0	4-CH3	3-CI	3.07 ± 0.48
a5	N	0	3-CH3	3-CI	9.43 ± 0.80
a6	N	0	3-CH3	4-NO2	15.47 ± 1.52
a7	N	0	3, 4-Me2	3-CI	0.99 ± 0.03
a8	N	0	3, 4-Me2	3-CF3	1.85 ±0.08
a9	N	0	4-i-Pr	3-CI	>100
a10	N	0	4-t-Bu	3-CI	>100
a11	N	0	4-t-Bu	3-CF3	>100
a12	N	0	4-t-Bu	4-CH3, 3-CI	>100
a13	N	0	2-F	3-CI	13.87 ± 1.03
a14	N	0	4-F	3-CI	9.74 ± 0.62
a15	N	0	3-CI	3-CI	6.73 ± 0.27
a16	N	0	3, 4-CI2	3-CI	6.05 ± 0.58
a17	N	0	3, 4-CI2	H	17.62 ± 1.24
a18	N	1	H	H	31.50 ± 1.65
b1	C	1	3-CI	H	7.74 ± 0.25
b2	C	1	2-F	H	14.11 ± 0.42
b3	C	1	4-CH3	H	5.16 ± 0.45
b4	C	1	3-CH3	H	7.39 ± 0.38