Table 2. Subgroup analyses for comparing survival between conventional and nerve sparing radical surgery for cervical cancer.
| Category | No. of studies | HR | 95% CI | Heterogeneity | Model used | |
|---|---|---|---|---|---|---|
| p-value | I2 | |||||
| Disease-free survival | ||||||
| Study design, and quality of study (NOS) | ||||||
| Prospective and NOS=8 | 3 | 1.026 | 0.673-1.565 | 0.468 | <0.001 | Fixed effect |
| Surgical approach | ||||||
| Laparotomy | 3 | 1.038 | 0.666-1.618 | 0.403 | <0.001 | Fixed effect |
| Radicality | ||||||
| Type III or C | 2 | 1.003 | 0.635-1.585 | 0.228 | 31.146 | Fixed effect |
| Adjustment for potential confounding factors | ||||||
| Age, adjuvant treatment, extent of lymphadenectomy, FIGO stage, LNM | 2 | 1.453 | 0.691-3.054 | 0.598 | <0.001 | Fixed effect |
| Overall survival | ||||||
| Study design, and quality of study (NOS) | ||||||
| Prospective, and NOS=8 | 3 | 1.075 | 0.433-2.611 | 0.054 | 65.805 | Random effects |
| Surgical approach | ||||||
| Laparotomy | 3 | 1.124 | 0.422-2.944 | 0.044 | 68.098 | Random effects |
| Radicality | ||||||
| Type III or C | 3 | 0.862 | 0.324-2.293 | 0.095 | 57.436 | Random effects |
| Adjustment for potential confounding factors | ||||||
| Age, adjuvant treatment, extent of lymphadenectomy, FIGO stage, LNM | 2 | 1.680 | 0.862-3.274 | 0.774 | <0.001 | Fixed effect |
CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; HR, hazard ratio; LNM, lymph node metastasis; NOS, the Newcastle-Ottawa Scale.