Supplementary Table 3. Demographic characteristics of 20 included studies.
| Study | Period of enrollment | Study design | FIGO stage | Surgical approach or type | Radicality | Sample size | Adjustment of potential confounding factors | |
|---|---|---|---|---|---|---|---|---|
| Conventional | Nerve sparing | |||||||
| Possover et al. (2000) [16] | 1996- | Prospective | IB2-IIA | LPS RH | III | 28 | 38 | Length of resected parametrium |
| Trimbos et al. (2001) [7] | 2000 | Prospective | Not mentioned | LPT RH | III | 2 | 8 | Age, adjuvant treatment, BMI, histology, NAC, tumor size |
| Querleu et al. (2002) [21] | 1991-1995* | Retrospective | IA2-II | LPS RH or RT | II | 47 | 48 (RT, n=13) | Extent of lymphadenectomy, FIGO stage, LNM, LVSI, no. of resected LNs, parametrial invasion, positive resection margin, tumor size |
| 1996-† | ||||||||
| Todo et al. (2006) [22] | 2000-2002 | Retrospective | IB1-IIB | LPT RH | III | 5 | 22 | Age, adjuvant treatment, extent of lymphadenectomy, FIGO stage, length of resected vagina, tumor size |
| Raspagliesi et al. (2006) [10] | Not mentioned | Retrospective | IB1-III | LPT RH | III | 20 | 59 (NAC, n=4) | Age, BMI, extent of lymphadenectomy, FIGO stage, grade, histology, LVSI, parametrial invasion, parity, positive resection margin, tumor size |
| Pieterse et al. (2008) [9] | 2006 | Prospective | I-IIA | LPT RH | III | 13 | 10 | Adjuvant treatment, menopause |
| Van den Tillaart et al. (2009) [17] | 1994-1999* | Prospective | I-IIA | LPT RH | III | 124 | 122 | Age, adjuvant treatment, depth of stromal invasion, extent of lymphadenectomy, FIGO stage, histology, LNM, LVSI, parametrial invasion, positive resection margin, tumor size |
| 2001-2005† | ||||||||
| Cibula et al. (2010) [23] | 2006-2008 | Retrospective | IA2-IIB | LPT RH or RP (7.1%) or RT (14.1%) | C | 19 | 35 | Age, adjuvant treatment, BMI, extent of lymphadenectomy, no. of resected LNs, tumor size |
| Espino-Strebel et al. (2010) [24] | 2002-2007 | Retrospective | IB1 | LPT RH | C | 52 | 27 | Extent of lymphadenectomy, depth of stromal invasion, parametrial invasion, positive resection margin, tumor size |
| Liang et al. (2010) [25] | 2006-2009 | Retrospective | IA2-IB2 | LPS RH | C | 81 | 82 | Age, BMI, extent of lymphadenectomy, FIGO stage, histology, length of resected parametrium, length of resected vagina, no. of resected LNs, tumor size |
| Skret-Magierlo et al. (2010) [18] | 2007-2008 | Prospective | IB1-IIA | LPT RH | III | 10 | 10 | Age, adjuvant treatment, BMI, extent of lymphadenectomy, FIGO stage. histology, LVSI, no. of resected LNs, tumor size |
| Wu et al. (2010) [11] | 2007-2008 | RCT | IB1-IIA | LPT RH | III | 15 | 14 | Age, adjuvant chemotherapy or radiotherapy, body mass index, extent of lymphadenectomy, FIGO stage, histology, LVSI, lymph node metastasis |
| Cibula et al. (2011) [26] | 2003-2007 | Retrospective | IA-IIB | LPT RH, RP (6.3%) or RT (4.7%) | B or C | 17‡ | 175§ | - |
| Ditto et al. (2011) [27] | 1980-1995* | Retrospective | IA2-IIB | LPT RH | III | 311 (NAC, n=56) | 185 (NAC, n=162) | Age, depth of stromal invasion, extent of lymphadenectomy, FIGO stage, histology, LNM, LVSI, parametrial invasion, positive resection margin |
| 2001-2009† | ||||||||
| Ceccaroni et al. (2012) [28] | 1997-2009 | Retrospective | IA2-IIB | LPS or LPT RH | III | 31 (NAC, n=3) | 25 (NAC, n=4) | Age, adjuvant treatment, extent of lymphadenectomy, FIGO stage, grade, histology, NAC, no. of resected LNs, surgical approach |
| Chen et al. (2012) [13] | 2007-2008 | RCT | IB1-IIA | LPT RH | III | 13 | 12 | Age, adjuvant treatment, BMI, FIGO stage, LNM, positive resection margin |
| Tseng et al. (2012) [19] | 2010-2011 | Prospective | IA2-IB1 | LPT RH | C | 12 | 18 | Age, extent of lymphadenectomy, histology, LNM, parametrial invasion, positive resection margin, tumor size |
| Pieterse et al. (2013) [29] | 1998-2008 | Retrospective | IA-IIB | LPT RH | III | 106 (>stage IIB, n=1) | 123 | Age, adjuvant treatment, FIGO stage, hormone replacement therapy, menopause |
| Bogani et al. (2014) [20] | 2004-2012 | Prospective | IA-IIB | LPS RH | II or III | 63 (NAC, n=12) | 33 (NAC, n=7) | Age, adjuvant treatment, BMI, extent of lymphadenectomy, FIGO stage, grade, histology, length of resected parametrium, length of resected vagina, LNM, NAC |
| Wang et al. (2014) [30] | 2008-2012 | Retrospective | IB1-IIA | LPT RH | III | 160 (NAC, n=42) | 78 (NAC, n=25) | Age, adjuvant treatment, BMI, depth of stromal invasion, extent of lymphadenectomy, FIGO stage, histology, LNM, NAC, ovarian transposition, parametrial invasion, positive resection margin |
BMI, body mass index; FIGO, International Federation of Gynecology and Obstetrics; LN, lymph node; LNM, lymph node metastasis; LPS, laparoscopy; LPT, laparotomy; LVSI, lymphovascular space invasion; NAC, neoadjuvant chemotherapy; RCT, randomized controlled trial; RH, radical hysterectomy; RP, radical parametrectomy; RT, radical trachelectomy.
*Conventional radical surgery was performed. †Nerve sparing radical surgery was performed. ‡Type C2 radical surgery was performed. §Type B or C1 radical surgery was performed.