Supplementary Table 4. Subgroup analyses for comparing clinical outcomes between conventional and nerve sparing radical surgery for cervical cancer.
| Category | No. of studies | SDM or OR | 95% CI | Heterogeneity | Model used | |
|---|---|---|---|---|---|---|
| p-value | I2 | |||||
| Blood loss (SDM) | ||||||
| Study design | ||||||
| RCT | 2 | -0.405 | -0.945 to 0.135 | 0.605 | <0.001 | Fixed effect |
| Prospective | 3 | -0.022 | -0.235 to 0.191 | 0.960 | <0.001 | Fixed effect |
| Retrospective | 5 | -0.374 | -0.683 to 0.066 | 0.068 | 54.220 | Random effects |
| Quality of study (NOS) | ||||||
| ≥8 | 5 | -0.332 | -0.656 to 0.009 | 0.006 | 72.541 | Random effects |
| <8 | 3 | -0.018 | -0.383 to 0.347 | 0.954 | <0.001 | Fixed effect |
| Surgical approach | ||||||
| Laparotomy | 7 | -0.093 | -0.271 to 0.085 | 0.842 | <0.001 | Fixed effect |
| Laparoscopy | 2 | -0.395 | -1.014 to 0.224 | 0.019 | 81.924 | Random effects |
| Radicality | ||||||
| Type III or C | 9 | -0.297 | -0.536 to 0.057 | 0.041 | 50.258 | Random effects |
| Adjustment for potential confounding factors | ||||||
| Age, BMI, FIGO stage | 5 | -0.339 | -0.655 to 0.024 | 0.103 | 48.091 | Fixed effect |
| Age, BMI, extent of lymphadenetomy, FIGO stage | 4 | -0.346 | -0.717 to 0.024 | 0.056 | 60.430 | Fixed effect |
| Hospital stay (SDM) | ||||||
| Study design | ||||||
| Prospective | 2 | -0.096 | -0.476 to 0.284 | 0.725 | <0.001 | Fixed effect |
| Retrospective | 4 | -0.259 | -0.459 to 0.060 | 0.676 | <0.001 | Fixed effect |
| Quality of study (NOS) | ||||||
| ≥8 | 3 | -0.244 | -0.449 to 0.039 | 0.446 | <0.001 | Fixed effect |
| <8 | 3 | -0.166 | -0.512 to 0.180 | 0.798 | <0.001 | Fixed effect |
| Surgical approach, and type | ||||||
| Laparotomy, and type III or C | 5 | -0.258 | -0.453 to 0.064 | 0.822 | <0.001 | Fixed effect |
| Adjustment for potential confounding factors | ||||||
| Age, BMI, extent of lymphadenetomy, FIGO stage | 4 | -0.233 | -0.436 to 0.030 | 0.574 | <0.001 | Fixed effect |
| Postoperative complications (OR) | ||||||
| Study design | ||||||
| Prospective | 3 | 0.452 | 0.269 to 0.761 | 0.473 | <0.001 | Fixed effect |
| Retrospective | 5 | 1.157 | 0.715 to 1.874 | 0.860 | <0.001 | Fixed effect |
| Quality of study (NOS) | ||||||
| ≥8 | 4 | 0.684 | 0.460 to 1.016 | 0.155 | 42.800 | Fixed effect |
| <8 | 4 | 1.082 | 0.492 to 2.380 | 0.353 | 8.005 | Fixed effect |
| Radicality | ||||||
| Type III or C | 7 | 0.696 | 0.482 to 1.005 | 0.288 | 18.594 | Fixed effect |
| Adjustment for potential confounding factors | ||||||
| Age, BMI, extent of lymphadenectomy, FIGO stage | 4 | 0.868 | 0.496 to 1.522 | 0.543 | <0.001 | Fixed effect |
BMI, body mass index; CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; NOS, the Newcastle-Ottawa Scale; OR, odds ratio; RCT, randomized controlled trial; SDM, standard difference in mean.