Table 2. Association between human papillomavirus viral load and clinicopathologic characteristics.
| Characteristic | Low HPV viral load group (n=173) (HPV viral load ≤132.5 RLU/CO) | High HPV viral load group (n=173) (HPV viral load >132.5 RLU/CO) | p-value |
|---|---|---|---|
| HPV viral load (RLU/CO), median (range) | 23.1 (1.1-131.8) | 677.7 (133.2-3,318.3) | |
| Age (yr) | 0.237 | ||
| Median (range) | 44 (22-86) | 45 (24-68) | |
| ≤44 | 93 (53.8) | 82 (47.4) | |
| >44 | 80 (46.2) | 91 (52.6) | |
| FIGO stages | 0.495 | ||
| IA2-IB | 122 (70.5) | 128 (74.0) | |
| IIA-IIB | 50 (28.9) | 45 (26.0) | |
| IIIA | 1 (0.6) | 0 (0) | |
| Histologic grade | 0.200 | ||
| Well | 7 (4.1) | 11 (6.4) | |
| Moderate | 53 (30.6) | 68 (39.3) | |
| Poor | 105 (60.7) | 86 (49.7) | |
| Unclassified | 8 (4.6) | 8 (4.6) | |
| Histologic type | 0.077 | ||
| Squamous cell carcinoma | 146 (84.4) | 159 (91.9) | |
| AD/ASC | 25 (14.4) | 12 (6.9) | |
| Others* | 2 (1.2) | 2 (1.2) | |
| Tumor size (cm) | 0.132 | ||
| ≤4 | 152 (87.9) | 142 (82.1) | |
| >4 | 21 (12.1) | 31 (17.9) | |
| Depth of stromal invasion | 0.024 | ||
| ≤Two-thirds | 99 (57.2) | 78 (45.1) | |
| >Two-thirds | 74 (42.8) | 95 (54.9) | |
| Lymph node metastasis | 0.496 | ||
| Negative | 137 (79.2) | 142 (82.1) | |
| Positive | 36 (20.8) | 31 (17.9) | |
| lymphovascular space invasion | 0.026 | ||
| Negative | 163 (94.2) | 151 (87.3) | |
| Positive | 10 (5.8) | 22 (12.7) | |
| Parametrial involvement | 0.311 | ||
| Negative | 167 (96.5) | 170 (98.3) | |
| Positive | 6 (3.5) | 3 (1.7) | |
| Vaginal resection margin | 0.474 | ||
| Negative | 168 (97.1) | 170 (98.3) | |
| Positive | 5 (2.9) | 3 (1.7) |
Values are presented as number (%).
AD/ASC, adenocarcinoma/adenosquamous carcinoma; FIGO, International Federation of Gynecology and Obstetrics; HPV, human papillomavirus; RLU/CO, relative light unit/cutoff.
*Neuroendocrine carcinoma and sarcomatoid carcinoma.