Table A1.

Characterization of the Genotypes of BAGS Subtypes

Genetic Analysis	Naive	Centroblast	Centrocyte	Memory	Plasmablast	Unclassified	Total
Base pairs affected by CNA in MDFCI (n = 165), %*
GCB	1.1	11.9	6.9	1	4	8.3
ABC	9.4	10.1	14.2	12.5	4.2	8.6
Unclassified	3.6	8.3	9.7	2.8	2.4	5
Total	6.4	11.2	9.1	8	3.8	7.7
All samples in MDFCI (n = 165), No.
Clean	5	0	7	0	7	4	23
Complex	3	13	20	3	1	4	44
NA	4	23	34	6	13	18	98
GCB samples in MDFCI (n = 75), No.
Clean	1	0	4	0	1	0	6
Complex	0	9	8	0	0	0	17
NA	2	18	20	1	3	8	52
ABC samples in MDFCI (n = 53), No.
Clean	3	0	1	0	6	3	13
Complex	3	2	7	3	1	3	19
NA	1	2	4	2	6	6	21
TP53 status in MDFCI samples (n = 165), No.
Absent	9	32	45	6	19	23	134
Indel	1	0	2	0	0	0	3
Mutant	0	2	12	2	2	3	21
NA	2	2	2	1	0	0	7
Mutation status in CHEPRETRO samples (n = 61-89), No.
MYD88 mutation	1	2	3	0	2	2	10
MYD88 wt	1	11	22	3	7	7	51
EZH2 mutation	0	4	3	0	0	0	7
EZH2 wt	2	14	32	4	16	14	82
CD79B mutation	1	0	2	1	3	1	8
CD79B wt	1	17	29	3	12	11	73

NOTE. The U133 and SNP6 paired samples (n = 165) from MDFCI data set¹⁹ were reanalyzed and assigned to BAGS.

Abbreviations: ABC, activated B-cell–like; BAGS, B-cell–associated gene signature; CHEPRETRO, Chemotherapy Prediction in Retrospective Samples; CNA, copy number alteration; GCB, germinal center B-cell–like; MDFCI, Mayo Clinic, Brigham and Women's Hospital, and Dana-Farber Cancer Institute Project; NA, not analyzed; wt, wild type.

^*The average percentage of base pairs affected by copy number changes stratified against ABC/GCB classification and BAGS subtype. The human genome was set to 3 × 10⁹ base pairs.