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. 2015 Jan 14;40(6):1405–1416. doi: 10.1038/npp.2014.326

Figure 1.

Figure 1

The effects of glycine on core temperature and sleep in a new cage environment. Core body temperature (a) and locomotor activity (b) were recorded from 60 min before cage exchange. All values are the mean±SEM (N=7). (c) Wake (left), NREM (middle), and REM (right) sleep amount changes are shown as the percentage of time spent in each stage every 30 min after oral administration of vehicle and 2 g/kg glycine (N=7 each). Amount (d), total episode number (e), and mean duration (f) of each stage during the first 90 min after oral administration. Glycine treatment significantly increased NREM sleep compared with vehicle during the first 90 min after administration, but it had no effect on all parameters after 90 min. Asterisks indicate significant difference (*p<0.05, **p<0.01). (g) NREM sleep latency was defined as the time from oral administration to the first appearance of a NREM sleep episode lasting longer than 1 min. (h) The distribution of EEG power during NREM and REM sleep. The data include all artifact-free sleep epochs during the first 2 h after oral administration. (i) Glycine administration significantly decreased core body temperature compared with vehicle.